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30th March 2008 - New research

ADVERSE EVENTS AFTER DBS SURGERY

Movement Disorders [2008] 23 : 343-349 (A Videnovic, L Verhagen Metman) Complete abstract

DBS is a surgical method of treating Parkinson's Disease that uses electrodes implanted into the brain. For more information go to Deep Brain Stimulation. Traditionally, the two most common sites in the brain used in surgery are the subthalamic nucleus (STN) and the globus pallidus interna (GPi).  The authors analysed reports of adverse events from over a thousand patients who had undergone DBS surgery. The most common adverse events were, in order : weight gain, then confusion, then speech difficulties. Neither part of the brain that was used had clearly fewer adverse events than the other.  Adverse events related to DBS surgery are common, but the study authors concluded that their true prevalence cannot be accurately determined with current reporting methods. For more information go to the Complete article  The most common adverse events were :

Procedure related events (% of STN / % of GPi) : Mental status / behaviour (mostly confusion) 18% / 9%, Infection 2% / 3%, ICH-symptomatic 2% / 4%, Misplaced electrode 2% / 2%, Speech disturbance 2% / 4%, Infarction 1% / 2%.

Stimulation or progression related events (% of STN / % of GPi) : Weight gain 37% / 18%, Dysarthria (speech disorder) 13% / 12%, Eye opening apraxia 11% / 0%, Gait ignition failure 0% / 17%.

Hardware-related events (Combined % of STN and GPi) : One or more events 9%, Infection 2%, Malfunctioning 1%, Lack of benefit 1%.

 

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Parkinson's Disease details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease : Parkinsonism, Essential Tremor, Dystonia, Restless Legs Syndrome, and Dementia. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports.

                                    

 

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