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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail [email protected].

                                           

 

31st December 2015 - New research

PRE-MOTOR SYMPTOMS OF PARKINSON'S DISEASE

 CLICK HERE FOR A PRINTABLE OR WHITE BACKGROUND VERSION OF THIS ARTICLE

Parkinson's disease is characterised by motor and non-motor clinical features. The latter may present as pre-motor symptoms several years before the onset of motor symptoms. Pre-motor symptoms have been found to be associated to a later motor onset of Parkinson's Disease.

The overall frequency of pre-motor symptoms was 76%. Among the most prevalent symptoms were depression (38%), sleep disorders (37%) and anxiety (36%). The time prior to motor onset was greatest for constipation (9 years) and pain (8 years). 
People with more than two pre-motor symptoms had a later age at motor onset when compared to people without pre-motor symptoms (56 v 52). Late onset patients had a higher frequency of pre-motor symptoms (79% v 65% in early onset) and worse symptoms than early onset. Females reported a higher number of pre-motor symptoms (1.9 v 1.4). Anxiety lead-time was greater in tremor-dominant compared to bradykinetic-rigid patients (3 years).

Pre-motor symptoms load is associated to a later motor onset of PD.  Pre-motor symptoms are more frequent in subjects with late onset Parkinson's disease. Female subjects report a higher number of pre-motor symptoms, depression and anxiety being the most common.

Reference : Journal of Parkinson's Disease [2015] Dec 10 [Epub ahead of print] (M.Rodríguez-Violante, A.J.de Saráchaga, A.Cervantes-Arriaga, R.Millán-Cepeda, R.Leal-Ortega, I.Estrada-Bellmann, C.Zuñiga-Ramírez)   Complete abstract  For more news go to Parkinson's Disease News

 

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2015-12-31 15:04:41
 
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