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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail mail@viartis.net.

                                           

 

31st December 2017 - New research

CAMICINAL INCREASES L-DOPA LEVELS IN PARKINSON'S DISEASE

 CLICK HERE FOR A PRINTABLE OR WHITE BACKGROUND VERSION OF THIS ARTICLE

Delayed gastric emptying can impair absorption of L-dopa, thereby contributing to motor fluctuations. Camicinal (GSK962040), is a gastroprokinetic, which is being assessed for its effect on the absorption of L-dopa and the symptoms of Parkinson's Disease. Gastroprokinetic drugs increase the movement of ingested material through the GI tract.

Patients were given either 50mg camicinal daily for 7 to 9 days or were taking a placebo. Average time to reach maximum L-dopa concentration by taking camicinal was reduced, indicating more rapid absorption of L-dopa.

Camicinal resulted in significant reduction in OFF time, reducing it by 2 hours 18 minutes. There was a significant increase in ON time, increasing it by 1 hour 52 minutes. There was also a significant decrease in mean total MDS-UPDRS score (Parkinson's Disease symptoms). Camicinal treatment was generally well tolerated.

Parkinson's Disease symptom improvement with the use of camicinal occurred in parallel with a more rapid absorption of L-dopa. This study provides evidence of an improvement of the motor response to L-dopa in people with Parkinson's Disease treated with camicinal

Reference : Movement Disorders [2017] Dec 26 [Epub ahead of print] (S.L.Marrinan, T.Otiker, L.S.Vasist, R.A.Gibson, B.K.Sarai, M.E.Barton, D.B.Richards, P.M.Hellström, D.Nyholm, G.E.Dukes, D.J.Burn) Complete abstract   For more news go to Parkinson's Disease News

 

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2017-12-31 00:28:04
 
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