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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail mail@viartis.net.

                                           

 

25th April 2018 - New research

MICROTABLET DISPENSER FOR MORE PRECISE L-DOPA DOSAGE

 CLICK HERE FOR A PRINTABLE OR WHITE BACKGROUND VERSION OF THIS ARTICLE

A study has assessed the effect of introducing a microtablet dose dispenser and adjusting doses based on the monitoring of motor symptoms in people with Parkinson's Disease. Forms of L-dopa are usually limited to certain doses and are consequently not adaptable to needs. A microtablet dose dispenser enables more precise doses of L-dopa.

Daytime doses of L-dopa were replaced with L-dopa / carbidopa microtablets, 5mg / 1.25 mg delivered from a dose dispenser device with programmable reminders. After two weeks, doses were adjusted based on ambulatory accelerometry and clinical monitoring. The daily L-dopa dose was increased by 15% from period 1 to 2, and the dose interval was reduced by 12%. The MDS-UPDRS parts II and III, disease-specific quality of life (PDQ-8), wearing-off symptoms (WOQ-19), and nonmotor symptoms improved after dose increases.

Evaluation of accelerometry results demonstrated improvement in 60% of subjects and worsening in 25% of them. The introduction of an L-dopa microtablet dispenser and accelerometry aided dose adjustments Parkinson's Disease improve symptoms and quality of life in the short term.

Reference : CNS Neuroscience and Therapeutics [2018] 24 (5) : 439-447 (D.Jan Johansson, A.Ericsson, A.Johansson, A.Medvedev, D.Nyholm, F.Ohlsson, M.Senek, J.Spira, I.Thomas, J.Westin, F.Bergquist) Complete abstract  For more news go to Parkinson's Disease News

 

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2018-04-25 21:05:58
 
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