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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail mail@viartis.net.

                                           

 

8th July 2018 - New research

AN ASSESSMENT OF HAVING PARKINSON'S DISEASE FOR 35 YEARS

 CLICK HERE FOR A PRINTABLE OR WHITE BACKGROUND VERSION OF THIS ARTICLE

An assessment was carried out of the clinical, neuropsychological, electrophysiological, and neuroimaging features of Parkinson's Disease since the onset of motor symptoms in people who had Parkinson's Disease for over 35 years.

The patients who were assessed had been treated with L-dopa and subthalamic nucleus deep brain stimulation (STN-DBS). Despite the amount of time that had elapsed there was still a sustained motor response to L-dopa (range 14%-35%), a sustained response to STN-DBS (range 23%-38%), and also to L-dopa plus STN-DBS (37%-63%). There were mild to moderate non-motor symptoms (within a range of 19 to 83 on a scale of 0 to 360), and autonomic dysfunction (within a range of 8-28 on a scale of 0-69). Two patients were demented, one had mild cognitive impairment, and two were cognitively preserved. Three of the patients had a peripheral neuropathy and two had a moderate-to-severe autonomic neuropathy. Their genetic tests were unremarkable.

Even after more than 35 years of having Parkinson's Disease, L-dopa and STN-DBS remained effective to some extent, and were even more effective in combination, on the cardinal symptoms of Parkinson's Disease.

Reference : Journal of Neurology [2018] Jun 26 [Epub ahead of print] (A.Romagnolo, M.Fabbri, A.Merola, E.Montanaro, S.Palermo, T.Martone, A.Seresini, S.Goldwurm, M.G. Rizzone, L.Lopiano)   Complete abstract  For more news go to Parkinson's Disease News

 

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2018-07-08 14:14:43
 
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