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MAY 2011 ������������������ ������������������������������������������������������������������������������������������������������������������������������ 28th May 2011 - News release NLX-P101 CLINICAL TRIAL DATA FOR PARKINSON'S DISEASE
Neurologix have provided details of a Phase 2 clinical trial of NLX-P101 in
Parkinson's Disease. NLX-P101 is a gene therapy under investigation for the
treatment of Parkinson's Disease. NLX-P101 increases the level of GABA,
NLX-P101 led to an average improvement of 23% in those people treated, which is an 8 point reduction from their symptom questionnaire score. Those patients undergoing sham surgery (those that were untreated) had an average improvement of nearly 13%, which is nearly a 5 point reduction from their symptom questionnaire score.� Therefore the average improvement beyond that of doing nothing was only actually 10% and occurred in only just over half of patients. For more information go to the News release. In order to refer to this article on its own click here. � 25th May 2011 - News release PROSAVIN CLINICAL TRIAL DATA FOR PARKINSON'S DISEASE
Oxford BioMedica, a leading gene therapy company, have announced clinical data
from a Phase I/II clinical trial of ProSavin for the treatment of Parkinson�s
Disease. They claim : an average improvement in motor
function of 43%, a maximum improvement of 61%, an increase in "on" time of 3
hours, and an decrease in "off"
However, only nine patients have so far been tested, and only for part of the intended duration of the clinical trial. The claim of increased "on" time and decreased "off" time has come only from two patients, and had been entirely self reported by the patients themselves. The claim of an average improvement in motor function of 43%, and a maximum improvement of 61% comes from only three of the patients who have been tested for the least time. It was not the actual average improvement of the patients, which was much less. Those patients tested for the longest actually declined in their improvement as time wore on. In order to refer to this article on its own click here. � 23rd May 2011 - New review MISDIAGNOSIS IN PARKINSON'S DISEASE
Misdiagnosis in Parkinson's Disease is very common. Initial diagnoses of
Parkinson's Disease made by general neurologists were only infrequently changed
[reference
1],
yet were incorrect in 24% to 35% of cases
[reference
1]�
[reference
2].
This means that many people have been treated for Parkinson's Disease for the
rest of their lives without ever having had Parkinson's Disease. In people
taking Parkinson's Disease drugs, Parkinsonism was confirmed in only 74% of
cases and only 53% of them had probable Parkinson's Disease. Over a quarter of
the
� 15th May 2011 - New research RETINAL STEM CELLS FAIL TO RID PARKINSON'S DISEASE Lancet Neurology [2011] May 10 [Epub ahead of print] (Gross RE, Watts RL, Hauser RA, Bakay RA, Reichmann H, von Kummer R, Ondo WG, Reissig E, Eisner W, Steiner-Schulze H, Siedentop H, Fichte K, Hong W, Cornfeldt M, Beebe K, Sandbrink R) Complete abstract Human retinal pigment epithelial (RPE) cells in the eyes also produce L-dopa. So their transplantation into the brain of people with Parkinson's Disease was considered to be able to improve the continuity of the administration of L-dopa better than the use of oral L-dopa. Researchers aimed to assess the safety, tolerability, and efficacy of transplantation of human retinal pigment epithelial cells into people with advanced Parkinson's Disease. Around 650,000 cells were injected in to the brain of each patient.� Each person's symptoms were then assessed after a year.
� 12th May 2011 - New research DID GENERAL MACARTHUR HAVE PARKINSON'S DISEASE ? Neurology [2011] 76 (19) : 1668-1672 (Bowen LN, Malaty IA, Rodriguez RL, Okun MS.) Complete abstract Historians have often claimed that General MacArthur had Parkinson Disease, and that his illness may have influenced his military judgment. General MacArthur (1880-1964) was Chief of Staff of the U.S. Army and played a prominent role as a Field Marshall in World War 2. For more information go to General MacArthur. It is already well established that Hitler had Parkinson's Disease throughout World War 2, and that he was preoccupied with it in the last days of World War 2. For more information go to Adolf Hitler and Parkinson's Disease.
� 7th May 2011 - New research DAYTIME SLEEPINESS TRIPLES THE RISK OF PARKINSON'S DISEASE
Sleep Medicine Reviews [2011] 15 (1) : 41-50 (S.Zoccolella, M.Savarese,
P.Lamberti, R.Manni, C.Pacchetti, G. Logroscino)
Complete abstract The researchers do not explain why excessive daytime sleepiness could lead to such an increased risk of Parkinson's Disease. However, it is known that melatonin, which is produced during sleep affects dopamine, the substance whose deficiency causes Parkinson's Disease. In order to refer to this article on its own click here. � 5th May 2011 - New research PARDOPRUNOX - A NEW DOPAMINE AGONIST FOR PARKINSON'S DISEASE
Movement Disorders [2011] May 3 [Epub ahead of print] (C.Sampaio, J.Bronzova,
R.A.Hauser, A.E.Lang, O. Rascol, S.V.van de Witte, A.A.Theeuwes)
Complete abstract
� 4th May 2011 - New book HANDBOOK OF ATYPICAL PARKINSONISM Carlo Colosimo (Editor), David E.Riley (Editor), Gregor K.Wenning (Editor)
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