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DECEMBER 2013 ���� ������������������������������������������������������������������������������������������������������������������������������ 29th December 2013 - New research L-DOPA PRODRUG FOR PARKINSON'S DISEASE Movement Disorders [2013] Dec 13 [Epub ahead of print (P.A.Lewitt, F.J.Huff, R.A.Hauser, D.Chen, D.Lissin, K.Zomorodi, K.C.Cundy)� Complete abstract
XP21279-carbidopa sustained-release bilayer tablets were developed to provide more continuous exposure to L-dopa. Once absorbed, XP21279 is rapidly converted into L-dopa. In a clinical trial of XP21279, people with Parkinson's Disease were given either XP21279 with carbidopa, or L-dopa with carbidopa, which as Sinemet is the most common means of treating Parkinson's Disease. The average daily off time was reduced more when using XP21279 but only by 18 minutes. There was little difference between the two in their effect on dyskinesia. However, XP21279 significantly reduced the variability of L-dopa concentration that occurs when using Sinemet (L-dopa and carbidopa). This was achieved by taking XP21279 only three times per day, instead of the four to five times a day that the L-dopa with carbidopa was taken. Therefore, overall, although L-dopa and carbidopa as Sinemet is the most common means of treating Parkinson's Disease, XP21279 was found to be more advantageous. In order to refer to this article on its own click here.��� � 28th December 2013 - New research FEMALE REPRODUCTIVE FACTORS AND THE RISK OF PARKINSON'S DISEASE Movement Disorders [2013] Dec 18 [Epub ahead of print] (R.Liu, D.Baird, Y.Park, N.D.Freedman, X.Huang, A.Hollenbeck, A.Blair, H.Chen)� Complete abstract In the largest ever study of its kind, researchers examined female reproductive factors and the risk of Parkinson's Disease. The study involved nearly 120,000 postmenopausal women aged 50 to 71 years.� The risk of developing Parkinson's Disease was not significantly associated with female reproductive factors including age at first menstruation, age at first live birth, and age at menopause generally.
� 20th December 2013 - New review PESTICIDES ON AIRCRAFT AS A CAUSE OF PARKINSON'S DISEASE Flight attendants who have developed Parkinson's Disease have taken legal action to try to prove that they have developed Parkinson's Disease because of the insecticides that are routinely sprayed inside� aircraft. For more information go to News report and News report Those pesticides that are known to cause, or be highly associated with Parkinson's Disease are Dieldrin, Rotenone and Organophosphorus pesticides. The fungicides Maneb and Paraquat are also known causes of Parkinson's Disease. Evidence in support of Permathrin, which is used in aircraft, is presently restricted to three animal studies.
� 19th December 2013 - New book DBS A PATIENT GUIDE TO DEEP BRAIN STIMULATION Sierra M.Farris, Monique L.Giroux
� 14th December 2013 - News release ANTIBODIES FOR THE TREATMENT OF PARKINSON'S DISEASE
Roche and Prothena are collaborating to co-develop antibodies for the
treatment of Parkinson's Disease. Prothena's antibody for the
treatment of Parkinson's disease,
PRX002,� targets alpha-synuclein. PRX002 is currently in
preclinical development. It is expected to enter Phase 1 clinical trials in
people with Parkinson's Disease in 2014. PRX002 has already been tested in
various cellular and animal models of synuclein-related disease. ���������������������������������������������������������������������������������������������������������������������������������������������������������������������������������������� 10th December 2013 - New book PARKINSON'S DISEASE TRAPPED - IT'S A GREY MATTER �Christopher C. Evans
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