27th February 2010 - New research
THE CHOICE OF DOPAMINE AGONISTS
FOR
PARKINSON'S DISEASE
Drug Safety [2010] 33 (2) : 147-161 (Kulisevsky J,
Pagonabarraga J.)
Complete abstract
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The tolerability and safety of ropinirole (Requip) in the treatment of
Parkinson's Disease, was compared to those of other dopamine agonists� (bromocriptine,
cabergoline,
pramipexole,
rotigotine,
pergolide),
the use of a placebo, and when used
alongside L-dopa. Thirty three
years worth of clinical trials were assessed. In all the studies included, dopamine agonists, including
ropinirole (Requip), exhibited a higher likelihood of adverse events than the use of a
placebo. The occurrence of constipation when using ropinirole (Requip) was only 55% of
that of bromocriptine (Parlodel), and 25% of that of L-dopa. There was no difference
between ropinirole (Requip) and rotigotine (Neupro) regarding constipation and dyskinesia. For
nausea, pergolide (Permax) was worse than ropinirole (Requip), but only
narrowly. Both were worse than rotigotine (Neupro). All were clearly worse than
the use of a placebo. Ropinirole (Requip) was worse than pramipexole (Mirapex)
regarding� nausea, dizziness, sleepiness and dyskinesia. Worst for
hallucinations was pergolide (Permax) then rotigotine (Neupro), then pramipexole
(Mirapex), and finally ropinirole (Requip). Hallucinations were far more likely
than when taking a placebo. Confusion and constipation were far worse with
pramipexole (Mirapex) compared with placebo. For more current news go
to
Parkinson's Disease News.
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all significant new research, news reports, new books, and new resources
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