24th January 2012 - New research
DEMENTIA IS LINKED TO INSULIN RESISTANCE IN
PARKINSON'S DISEASE
Journal of Neurological Science [2012] Jan 20.
[Epub ahead of print] (Bosco D, Plastino M, Cristiano D, Colica C, Ermio C, De
Bartolo M, Mungari P, Fonte G, Consoli D, Consoli A, Fava A.)
Complete abstract
Dementia has been found to be associated with insulin resistance in Parkinson's
Disease. Dementia commonly occurs in Parkinson's Disease when Parkinson's
Disease progresses. This is not inevitable because the biochemistry of
Parkinson's Disease and Dementia are completely distinct. There is therefore no
reason why they should coincide. Their common association has never been fully
explained apart from the fact that Dementia and Parkinson's Disease are both far
more common with age.
People
who have Parkinson's Disease and dementia were assessed for their resistance to
insulin. When insulin is produced in order to prevent high blood glucose levels,
insulin sometimes does not have affect. This can be due to insulin resistance,
which is the inability of insulin to stimulate the insulin receptors. Brain
function largely requires glucose in order to function. Nearly two thirds (62%)
of people with Parkinson's Disease who had dementia were found to have insulin
resistance. 30% of them also had impaired glucose tolerance. These percentages
were significantly higher when the disease duration was longer and when the
movement disability was worse. So dementia in Parkinson's Disease appears to be
affected by the inability to make use of glucose rather than be a direct result
of Parkinson's Disease.
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