Pardoprunox was taken in dosages of up to 42mg per day. Pardoprunox reduced OFF time by 1 hour 37 minutes per day, but even a placebo reduced the OFF time by 55 minutes per day. So the actual benefit of Pardoprunox beyond that of a placebo was a reduction in OFF time of only 42 minutes per day. Pardoprunox made no significant difference to scores on the PDQ-39, which assesses Parkinson's Disease symptoms.  There was a high drop-out rate (37% of people) due to adverse events suggesting that the selected dose range may have been too high, or that the increase in dose may have been too rapid. For more current news go to Parkinson's Disease News.

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