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Parkinson's Disease News covers
all significant new research, reports, books, and resources concerning
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29th July 2013 - New research
PRAMIPEXOLE
: EXTENDED RELEASE v IMMEDIATE RELEASE
Drug Research [2013] Jul 24 [Epub ahead of print] (M.Takanashi, Y.Shimo, T.Hatano,
G.Oyama, N.Hattori)
Complete abstract
Changing from Immediate release Pramipexole to Extended release Pramipexole
was found to cause a reduction in Parkinson's Disease symptoms. Pramipexole,
which is marketed as� Mirapex, Mirapexin, and Sifrol, is a dopamine
agonist used in the treatment of Parkinson's Disease. For more information
go to
Mirapex and
Mirapex ER.
This
study aimed to evaluate the efficacy and safety of an extended-release
tablet formulation of pramipexole (PPX-ER) given once daily when switched
from an immediate-release tablet formulation (PPX-IR) given 3 times daily.
The extended release version evens out the effect of Pramipexole.
Parkinson's Disease symptom scores were reduced after 4 weeks and after 8
weeks. There was no change in the nocturnal and early morning symptoms
(NEMS) score, or the Parkinson's Disease Sleep Scale (PDSS-2). Nearly two thirds of patients and caregivers preferred the extended
release version. For a printable
version of this article
click here.
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