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�PARKINSON'S DISEASE NEWS

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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail [email protected].

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9th September 2013 - New review

FUTURE FORMS OF L-DOPA FOR PARKINSON'S DISEASE

The forms of L-dopa presently being developed are likely to completely change the way that L-dopa is used. They include Inhaled L-dopa, Dual layer L-dopa, Subcutaneous L-dopa, L-dopa prodrug, Melevodopa and AcuForm.

Mucuna Pruriens has been a source of L-dopa since ancient times. As a drug, L-dopa started out as a treatment on its own. Sinemet and Madopar combined L-Dopa with a decarboxylase inhibitor in order to reduce the loss of L-dopa before it was used. In order to spread out the effect of L-dopa, controlled release versions of Sinemet and Madopar were then produced, Stalevo added Entacapone to that combination. Entacapone is a COMT inhibitor, which is able to slow down the degradation of L-dopa. An improved version of Stalevo called ODM-101 is already being developed. Parcopa is an orally disintegrating combination of L-dopa and carbidopa, which is the same combination as Sinemet. Duodopa is a combination of L-dopa and carbidopa in the form of a gel, which is administered throughout the day using a portable pump directly into the small intestine through a surgically placed tube.

New forms of L-dopa presently being developed for the treatment of Parkinson's Disease are :

  • Inhaled L-dopa (CVT-301), which is taken using an inhaler, enables a far quicker effect than existing forms of L-dopa. For more information go to Inhaled L-dopa

  • Dual layer L-dopa (IPX054), which includes the immediate release version of L-dopa and the controlled release version, is better than existing forms of L-dopa. For more information go to Dual layer L-dopa

  • Subcutaneous L-dopa (ND0612) is a combination of L-dopa and carbidopa in a liquid formula administered continuously sub-cutaneously through a patch pump. For more information go to Subcutaneous L-dopa

  • L-dopa prodrug (XP21279) is rapidly converted in to L-dopa only after it has been absorbed. This facilitates active and efficient absorption into the body. For more information go to L-dopa prodrug

  • Melevodopa is the methyl ester of L-dopa. As it is a soluble neutral derivative it overcomes the insolubility and acidity of L-dopa when used in continuous intravenous infusions. For more information Melevodopa

  • AcuForm in combination with L-dopa and carbidopa (DM-1992) makes use of the properties of polymers that help to deliver L-dopa over a longer period of time. For more information go to AcuForm

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2015-08-15 23:13:24
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