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Parkinson's Disease News covers
all significant new research, reports, books, and resources concerning
Parkinson's Disease.
Articles are chosen on the basis
of their medical significance or potential interest. Our overwhelming priority
is the facts, regardless of whether they contradict prevailing views or vested
interests. Analysis and further information are provided
either to explain the background or implications, or to
balance misleading claims. If you notice errors or inadequacies, or dispute what is
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9th April 2017 - New research
DEXTROMETHORPHAN FOR PARKINSON'S DISEASE DYSKINESIA
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Dextromethorphan/quinidine, whose trade name Nuedexta, is a combination drug
containing dextromethorphan and the antiarrhythmic agent quinidine.
Quinidine is included to inhibit dextromeththorphan metabolism. For more information go to
Nuedexta
This pilot-study (NCT01767129) examined the safety and efficacy of
dextromethorphan plus quinidine for treating L-dopa induced dyskinesia.
People with Parkinson's Disease were randomised to 45mg dextromethorphan and
10mg twice daily, alternated with a placebo.
 The
main assessment was dyskinesia severity. Dyskinesia severity was a bit lower
with dextromethorphan and quinidine than with a placebo, and subsequently
significantly lower. Most of the patients rated their dyskinesia "much or
very much improved" when taking dextromethorphan and quinidine.
Dextromethorphan and quinidine did not worsen Parkinson's Disease motor
scores, was generally well tolerated, but was associated with more frequent
adverse effects. This study provides preliminary evidence of clinical
benefit with dextromethorphan / quinidine for treating L-dopa induced
dyskinesia in Parkinson's Disease. Larger and longer studies are needed to
corroborate these findings.
Reference : Movement Disorders [2017] Mar 30
[Epub ahead of print] (S.H.Fox, L.V. Metman, J.G.Nutt, M.Brodsky,
S.A.Factor, A.E.Lang, L.E.Pope, N.Knowles, J.Siffert)
Complete abstract For more news go to
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