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Parkinson's Disease News covers
all significant new research, reports, books, and resources concerning
Parkinson's Disease.
Articles are chosen on the basis
of their medical significance or potential interest. Our overwhelming priority
is the facts, regardless of whether they contradict prevailing views or vested
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either to explain the background or implications, or to
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17th May - New research
LIQUID L-DOPA FOR PARKINSON'S DISEASE
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Liquid L-dopa is usually taken as a combination of L-dopa, carbidopa, and
ascorbic acid (vitamin C) in a solution called LCAS. Therapy with liquid
L-dopa has been used in people with advanced Parkinson's Disease for many
years. However, long-term follow-up information is scarce. The present study
aimed to determine the long-term retention rate for LCAS therapy, and to
identify the causes of LCAS therapy withdrawal.
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People with Parkinson's Disease were assessed who had undergone LCAS
treatment to alleviate motor complications that were not controlled
by optimised conventional Parkinson's Disease treatments. The three
main reasons for discontinuation of LCAS treatment were worsening of
wearing-off symptoms, persistent dyskinesia, and poor drug
adherence. However, there were a small number of each of these.
Around 37% of people maintained the LCAS treatment after 12 months.
In those people, on time without dyskinesia significantly increased
from 33% to 57% after the initiation of LCAS treatment. Around 31%
of patients were still receiving LCAS treatment after 30 months.
In order to refer to this article on its own
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Reference : Journal of Neurological Science
[2017] 377 : 6-11 (H.J.Yang, G.Ehm, Y.E.Kim, J.Y.Yun, W.W.Lee, A.Kim,
H.J.Kim, B.Jeon)
Complete abstract
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